Purified Anti-Human CD178 Antibody[NOK-1] (AN009640P)
| Alternate Names | ALPS1B, Apo I Ligand, Apoptosis (APO 1) antigen ligand 1, apoptosis (APO-1) antigen ligand, apoptosis (APO-1) antigen ligand 1, Apoptosis antigen ligand, Apoptosis antigen ligand 1, apoptosis(APO-1) antigen ligand, apoptosis(APO-1) antigen ligand 1, APT1LG, APT1LG1, APT1LG1CD95L, APTL, CD178, CD178 antigen, CD95 ligand, CD95-L, CD95L, CD95L protein, Fas antigen ligand, Fas L, Fas ligand, Fas ligand (TNF superfamily, Fas ligand (TNF superfamily member 6), FASL, Fasl Fas ligand (TNF superfamily member 6), FASLCD95 ligand, FASLG, Generalized lymphoproliferative disease, Gld, member 6), soluble Fas Ligand (sFasL), soluble form, TNFL6, TNFSF, TNFSF6, TNFSF6FasL, TNLG1A, Tumor necrosis factor (ligand) superfamily member 6, tumor necrosis factor ligand superfamily member, tumor necrosis factor ligand superfamily member 6 |
| Clone | |
| Verified Samples | Verified Samples in FCM: HEK293T cells transfected with pcDNA3.1 plasmid encoding Human CD178 gene |
| Dilution | FCM ≤ 0.2 µg per million cells in 100 µL volume |
| Background | Fas Ligand (FasL), also known as CD178, CD95L, or TNFSF6, is a transmembrane protein homotrimer that binds to Fas/CD95 and triggers apoptosis in the Fas-expressing cell. Fas Ligand also binds the soluble decoy receptor DcR3. It is expressed on activated Th1 cells, CD8+ cytotoxic T cells, and NK cells. A soluble form can be released which remains trimeric and retains the ability to bind Fas. Fas Ligand-induced apoptosis plays a central role in the development of immune tolerance and the maintance of immune privileged sites. Tumor cells can evade immune surveillance by upregulating Fas Ligand to kill tumor infiltrating lymphocytes. In gld mice, a Fas Ligand point mutation is the cause of severe lymphoproliferation and systemic autoimmunity. |
| Immunogen | Recombinant Human CD178 protein |
| Abbre | CD178 |
| Swissprot | |
| Host | Mouse |
| Reactivity | Human |
| Clonality | Monoclonal |
| Purification Method | >98%, Protein A/G purified |
| Isotype | Mouse IgG1, κ |
| Isotype Control | Purified Mouse IgG1, κ Isotype Control[MOPC-21] |
| Applications |
FCM
|
| Research Areas | Stem Cells;Immunology;Cell Biology;Cytokine and Growth Factors;Mitochondrial Pathway;Death Receptors Signaling Pathway;CDs;Hematopoietic Stem Cell Markers |
| Cellular Localization |
Cell membrane, Secreted
|
| Concentration |
≥ 1 mg/mL
|
| Conjugation | Unconjugated |
| Storage Buffer | Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling. |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. |
| Expiration Date | 12 months |
| Shipping | Ice bag |
Note: Data for this module come from published literature that cites this product, displaying other products used together in the same research paper.
Searching publications using CD178 as the keyword shows that the gene above is closely associated with CD178 in research. Results are sorted in descending order of research relevance. (The displayed numbers represent the number of publications in which both terms co-occur.)
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